Regioselectivity switch in chiral amine-catalysed asymmetric addition of aldehydes to reactive enals.
نویسندگان
چکیده
In this communication, we present a regioselectivity switch for the chiral amine-catalysed asymmetric addition of aldehydes to reactive enals to afford either aldol adducts or conjugate adducts in a stereoselective fashion. The unprecedented asymmetric aldol reaction of aldehydes with enals was realized by the use of a diarylprolinol catalyst, giving synthetically useful and important chiral allylic alcohols.
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عنوان ژورنال:
- Chemical communications
دوره 51 49 شماره
صفحات -
تاریخ انتشار 2015